DIFFERENTIAL AFFINITY CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY: A SUITABLE TOOL TO IDENTIFY COMMON BINDING PROTEINS OF A BROAD-RANGE ANTIMICROBIAL PEPTIDE DERIVED FROM LEUCINOSTATIN

Differential Affinity Chromatography Coupled to Mass Spectrometry: A Suitable Tool to Identify Common Binding Proteins of a Broad-Range Antimicrobial Peptide Derived from Leucinostatin

Leucinostatins are antimicrobial peptides with a broad range of activities against infectious agents as well as mammalian cells.The leucinostatin-derivative peptide ZHAWOC_6027 (peptide 6027) was tested in vitro and in vivo for activity against the intracellular apicomplexan parasite Toxoplasma gondii.While highly efficacious in vitro (EC50 = 2 Bos

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Insights into the occurrence of phylosymbiosis and co-phylogeny in the holobionts of octocorals from the Mediterranean Sea and Red Sea

Abstract Background Corals are the foundational species of coral reefs and coralligenous ecosystems.Their success has been linked to symbioses with microorganisms, and a coral host and its symbionts are therefore considered a single entity, called the holobiont.This suggests that there may be evolutionary links between corals and their microbiomes.

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